4009. Structure and Function of Biological Macromolecules
3.00 credits
Prerequisites: MCB 2000 or 3010, which may be taken concurrently, or instructor consent.
Grading Basis: Graded
Fundamentals of protein structure and the forces that stabilize structure. Topics include recurrent structural motifs, molecular ancestry/homology, evolution of protein structure, structure-function correlations, and the structural basis of regulation. Discussion of the techniques used to investigate structure, including X-ray diffraction, NMR, TEM, AFM, structure prediction, and computational simulations. Advanced topics may include chaperones, structural genomics and the roles of misfolded proteins in disease.
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